![]() This containment turns off the drugs' biological effects, said Isaacs.Īdditional work showed that P6AS can bind to many other drugs including MDMA, PCP, and mephedrone. Tests conducted in the lab and in animal models indicated that P6AS can sequester fentanyl and methamphetamine, which mitigates their effects. The compound is a molecular container that can attach to other chemicals and sequester them inside of a cavity. “That’s one of the huge opportunities for our compound.” “Opioids already have a reversal agent in naloxone, but there are a variety of non-opioid drugs of abuse like methamphetamine, PCP, mephedrone, ecstasy (MDMA) and cocaine that do not have a specific antidote,” said lead study author Lyle Isaacs, a professor at University of Maryland (UMD). Reporting in the journal Chem, scientists have shown that it could be used as an antidote for fentanyl and methamphetamine overdoses, and potentially counters other drugs as well. ![]() Scientists have now developed a more universal treatment that can counter the effects of drug overdoses, a compound called PillarMaxQ (P6AS). There is a drug called naloxone, which is sold as Narcan that can prevent opioid overdoses, and has already saved many lives. Deaths from synthetic opioids like fentanyl are increasing dramatically, while overdoses from other types of drugs have remained relatively steady. About 92,000 people died from drug and prescription opioid overdoses in 2020. Drug overdose deaths continue to rise in the United States.
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